DCA is a generic drug so (for-profit) pharmaceutical companies cannot invest 100 million dollars into a drug which will not make it any money. Note: generic drug means it has already been on the market for a long time so the patent expired and now all pharmaceutical companies can sell it.
Also if somehow DCA’s cancer applications are patentable the patent should belong to Dr. Michelakis’ team, which is to say if a patent hasn’t been obtained by him already. Because the co-operative is a not-for-profit pharmaceutical company it shouldn’t care whether it holds the patent or not as the end goal is the cure and not to make money.
In this exceptional case where the co-operative does not own the patent so it can’t control if it would be offered to the public at cost if it passes health authorities’ approval as a cancer treatment; but, in this exceptional case DCA is already a generic drug for other applications and it is cheap to make. It is unlikely it would be priced higher for its cancer applications than it would for its other applications.
There may or may not be legal implications of testing without a patent, I don’t really know. Just trying to think out of a man-made ‘box’ to test this drug as quickly and effectively as possible. I think I heard of other DCA tests being held in different parts of the world so this may be possible.
I have never contacted Dr. Michelakis about the Stickman Model so if he ever hears of this website it will surprise him. I once sent a very lame email about possibly holding a fundraiser for DCA but I never heard back from him and I am not even sure my email would have made it past the university’s spam filter.
Cell Information (as close to factual information you will get from me)
"There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease. Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation." Otto Warburg
A cell’s mitochondrion does many things including: it is responsible for producing the cell’s energy from oxygen, and for apoptosis – or programmed cell death. A cancer cell’s mitochondrion cannot do these functions correctly. All types of cancer cells (lung, breast, skin, etc.) are the same in this respect: the cell tries to get at least part of its energy from glucose (sugar), and it doesn't commit suicide like it is supposed to. We know this is true because a PET scan (machine used to detect all cancers) works on the core principle of finding cells using sugar for energy.
It would be a dream comes true if you could fix a cell’s mitochondrion and cure all cancers at the same time.
Source of information: don’t be so lazy, go find your own source… or you can cheat like I did and check out the sources of the website listed below
Why DCA is Worthy
Please see http://dcawatch.com/home/ for reasons why DCA stands out as a drug being worthy for a co-operative to test. But I want to caution you this site is written like mine – it is an opinion site so you will be receiving biased information. It is your responsibility to check out this site’s sources to form your own opinion on DCA. I don’t know this site’s author(s) and although I feel the information is heavily biased to try to get you to come to the same conclusions as the author(s) the quality of the sites sources are exceptional. I would caution this site is filled with both opinions and facts which can sometimes make it hard to see which is which.
Highlights I liked from this site are as following (quotes listed below are in random order)
“Sodium Dichloroacetate (DCA) is a simple molecule discovered by the University of Alberta to shrink tumors by reversing the Warburg Effect. Otto Warburg was one of the most respected scientists in the history of cancer research. He won a noble prize for his work on cancer cell metabolism.”
“The Warburg effect states that the difference between a normal cell and a cancer cell is simply that a cancer cell gets its energy from glucoses and a normal cell gets energy from oxygen, therefore fermentation is common to all cancer cells”
“The following quote is an excerpt from a lecture originally delivered by O. Warburg at the 1966 annual meeting of Nobelists at Lindau, Germany…
There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease. Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose.”
“All cancer breast, lung, liver, brain are all simply a collection of cells that are partial Anaerobes, they are different cells, lung cells or brain cells etc but they are all partial anaerobes which are now called cancer cells. At this point in history 1966 the only thing they didn’t know was that the effect could be reversed, which is the science behind DCA.”
The PET/CT scan machine “used to identify cancer and create a 3D image” was first developed in 1970…it’s use in Oncology is solely based on The Warburg Effect! Does the PET scan work? sure it does, therefore the Warburg effect is fact”
“With a PET scan the patient is injected with a Glucose-based Radiopharmaceutical, the patient is then put into a PET/CT scanner which identifies the areas were the cancer cells are as they are feeding off the glucose, accurate 3D tumor images can then be seen on a computer screen. Interestingly no research was focused on this simple concept of cancer cell metabolism until the University of Alberta discovered that NaDCA could switch the mitochondria of a cancer cell back on allowing it to commit suicide. The PET scan was developed in the early 70’s.”
“lets take a look at what the PET scan machine is used to diagnose, All types of Cancer, Heart disease such as coronary artery disease… a PET scan is also used to detect Brain disorders such as Alzheimer disease, Parkinsons disease, and epilepsy. Could NaDCA also be useful in the treatment of these brain disorders?”
“So the only thing they didn’t know in 1966 was that the mitochondria could be turned back on in a cancerous cell allowing the cell to cause apoptosis (cell suicide). This is exactly what NaDCA does, NaDCA does not kill the cancer! It turns the mitochondria back on so that the cancer cell kills itself.”
“Scientists and doctors have used DCA for decades to treat children with inborn errors of metabolism due to mitochondrial diseases. Mitochondria, the energy producing units in cells, have been connected with cancer since the 1930s, when researchers first noticed that these organelles dysfunction when cancer is present.
Until recently, researchers believed that cancer-affected mitochondria are permanently damaged and that this damage is the result, not the cause, of the cancer. But Michelakis, a cardiologist, questioned this belief and began testing DCA, which activates a critical mitochondrial enzyme, as a way to “revive” cancer-affected mitochondria.
The results astounded him.
Michelakis and his colleagues found that DCA normalized the mitochondrial function in many cancers, showing that their function was actively suppressed by the cancer but was not permanently damaged by it.”
“You will see that the U of Alberta’s small human trial achieved 100% response in tumor reduction, every last patient! But yet they say the sampling was not large enough to conclude DCA works, Really! Simply put, NaDCA works by turning off the cancer cells immortality and allowing it to kill itself”
“The most amazing item of note is that NaDCA altered the metabolism of the Glioblastoma cancer Stem Cells,……….No current cancer treatment is known to do this!
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